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SN74LVC1T45容易被击穿问题

Other Parts Discussed in Thread: SN74LVC1T45, SN74LVC2T45

以上是我的应用电路,左右两边是单片机IO口,VDD1为外部电源(范围3V~5V),但这样的低电压环境使用,SN74LVC1T45(U15)芯片也常被击穿损坏,请帮解释解释什么原因?或有什么防护措施建议?