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The difference between CC2640R2F and CC2640R2L is mainly that that the Sensor Controller Engine has been removed on the latter.
Meaning that if your existing code uses the Sensor controller you can't port to CC2640R2L, if it doesn't, it should be straight forward to move to the new device. Note that also some of the peripherals in AUX that the Sensor Controller typically use has been removed (comparator, current source).
