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SN65HVD888芯片的应用电路--基础问题

Other Parts Discussed in Thread: SN65HVD888, ISO7841

请问我们这款SN65HVD888芯片的应用电路,直接按照规格书上的这个图来设计,行不行?

 

因为有个项目现在由于工程接线的问题,只能在主从之间有两根线进行通信,方案要求设计接线就是这样。但考虑到主从机(室内机与室外机)两者的地是不一样的,这样的设计,会不会存在电势差而导致的串电影响的故障问题?

 基础问题,多谢解答