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To minimize leakage currents on the analog inputs, leave unused analog and reference inputs floating, or connect the inputs to mid-supply or to AVDD. AIN3/REFN1 is an exception. Leave the AIN3/REFN1 pin floating when not used in order to avoid accidently shorting the pin to AVSS through the internal low-side switch. Connecting unused analog or reference inputs to AVSS is possible as well, but can yield higher leakage currents than the previously mentioned options.
